Minzhen Xu, MD, PhD
Vice President, Biology

Minzhen Xu, as the senior founding experimental scientist of Antigen Express, has been an integral member of Antigen Express, Inc from it’s beginning. Dr. Xu received his MD from the Second Shanghai Medical School in China in 1978 and his PhD in Virology and Immunology from the University of Massachusetts Medical Center in 1991. His research at Antigen Express is focused on generating more potent vaccines and immunotherapies for infectious diseases and tumors. To accomplish this he is working on enhancing T helper cell activation by suppressing the expression of MHC class II-associated invariant chain and by coupling Ii-Key segment to MHC class II epitopes.

Douglas Powell, PhD
Director of Immunobiology

Doug Powell earned his PhD. in Genetics at the George Washington University and did his thesis research in the Laboratory of Immunoregulation at the National Institues of Health. He also completed a postdoctoral fellowship at the Gladstone Institutes of Virology at the University of California, San Francisco. Following his postdoctoral fellowship, Dr. Powell took a job at Dupont Pharmaceutical Company in Wilmington, Delaware in the Virology Laboratory where he worked on the development of antiviral drugs for the treatment of HIV/AIDS. He then joined Millennium Pharmaceuticals where he ran a program identifying cellular targets for therapeutic intervention in the treatment of HIV/AIDS. Dr. Powell recently joined Antigen Express where he is developing vaccine strategies for prevention of HIV infection and will also apply the vaccine technologies employed by Antigen Express for vaccines to prevent infection with other viruses including SARS, smallpox and other viruses that could be used as agents of biological terror.

Nikoletta L. Kallinteris, MS
Project Leader, Ii-Key Hybrid Technology

Nikoletta L. Kallinteris became a member of Antigen Express in November of 2000. Prior to that she attended the University of Pennsylvania - East Stroudsburg where she graduated Magna Cum Laude with a Bachelor’s degree in Pre-Medicine in 1997 and the University of Connecticut where she acquired a Master’s degree in Immunology in 2000. Nikoletta completed her Thesis in Dr. Robert Clark’s laboratory of autoimmune diseases at UConn Health Center. Her research focused on the autoimmune mediated pathology of Multiple Sclerosis relapse as related to T-cell biology. During the time of her thesis research, she taught biology laboratory courses at the University of Connecticut. Her mission at Antigen Express involves vaccine development applicable to malignant disease via novel characteristics of the MHC class II invariant chain (Ii) chain. She currently leads projects coupling an Ii-key moiety to antigenic epitopes of cancerous proteins enhancing Th1 immunogenicity.

Xueqing Lu, PhD
Research Scientist

Xueqing Lu joined Antigen Express in October of 2000. His research engages in the design and cloning of expressible antisense gene constructs into DNA vaccine vectors evaluated for Ii-suppression in situ. Dr. Lu also explores the induction of MHC class II(+)/Ii(-) phenotype via RNAi delivery into tumor cell lines. Xueqing received his PhD in Chemistry from Shanghai University of Chinese Traditional Medicine and Pharmacology in 1999.

Shuzhen Wu
Research Associate

Shuzhen Wu functions as versatile member of Antigen Express. Since her start in 2001, she has assisted in the evaluation of Ii-reverse gene constructs (Ii-RGCs) by transient and stable transfection using human and murine tumor cell lines. Her technical expertise in ELISA and FACS analysis along with cell culture maintenance and propagation have contributed tremendously to AE projects. Shuzhen received her Bachelors degree from Jiangxi Agricultural University in 1984.

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